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Can Sleep ‘Brainwash’ Away Toxins Tied to Alzheimer’s?

A lot of buzz dropped recently about new research into neurological mechanisms that occur during sleep.

Researchers at Boston University reported in a study published in 2019 that they found cerebrospinal fluid (CSF) presents itself as waves that wash into the brain as we doze.1

This “brainwashing” mechanism seems to serve a detoxifying purpose during slow-wave sleep, in particular.

How does this relate to Alzheimer’s disease (AD)?

What’s slow-wave sleep?

Slow-wave sleep is also known as stage 3, N3, nonREM stage 3 or delta sleep. This deepest of sleep stages has, as its chief purpose, the role of repairing the brain and body at the cellular level. The brain releases human growth hormone (HGH) at this time.

As we age, this sleep stage gradually shortens because the body and brain aren’t actively developing structurally in our later years. Children, on the other hand, enjoy large quantities of slow-wave sleep.

One undesired result of reduced slow-wave sleep: toxic buildup of certain kinds of proteins (such as beta amyloids) can damage brain cells.

If these clusters break apart from complete chains, they can reform as plaques on nerve cells in later life, as the result of ongoing sleep disturbances—which can cause cognitive dysfunction and memory problems, sometimes irreversibly so.2

It’s the presence of this amyloid buildup in the brain that’s positively linked to dementia and memory issues for people with AD and other neurological disorders.

What the Boston University research found

In this 2019 study, the scientists captured MRI evidence of blood flowing from the brain during slow-wave sleep, an exit that then prompted an incoming tide of CSF.1 These waves of fluid appear to flush the brain of toxins, among them those proteins well known to impair memory.

Study co-author Laura Lewis, who serves on both the biomedical engineering and systems neuroscience department faculties at Boston University, said that “the neural change always seems to happen first, and then it’s followed by a flow of blood out of the head, and then a wave of CSF into the head,”. She also said CSF pulsing during sleep “was something we didn’t know happened at all, and now we can just glance at one brain region and immediately have a readout of the brain state someone’s in.”

These findings have generated a great deal of excitement, as they may lead to a better understanding of how and why certain kinds of neurological conditions, like AD, connect biologically with disrupted sleep.

AD and sleep disorders: old news, but new ideas

Caregivers of loved ones with AD or other forms of dementia or cognitive dysfunction don’t need science to convince them that poor sleep is a big part of the dementia puzzle. They deal directly with nighttime wandering, sundowning, excessive daytime sleepiness and other sleep-wake behaviors consistent with AD.

Indeed, science has drawn these connections multiple times. The National Sleep Foundation (NSF) website highlights numerous ways in which disrupted sleep relates to AD.3 Well-known disorders linked to AD include circadian rhythm disruptions, poor sleep hygiene, sleep apnea, nocturia (frequent nighttime urination), and insomnia.

Some of these problems could be caused by AD, could be the result of AD, or could be linked to medications used to treat AD or other comorbid conditions.

What’s more, it’s also documented that seniors who use sleep aids to manage their sleep—especially over-the-counter diphenhydramine, such as Benadryl, “PM” pain relievers, nighttime cold medications, or ZZZquil—may contribute to the development of memory-related problems and early-onset dementia.4,5

However, knowing the links exist doesn’t mean neuroscientists know how or why they exist.

Enter the expertise of sleep medicine researchers, who’re poised to become major players in AD research.

In September 2019, research published by Elsevier highlighted the top 10 topic clusters for emerging Alzheimer’s research, and sleep health especially related to sleep-breathing disorders—was rated 6th in prominence.6

How to improve sleep in AD

Caregivers can strive to incorporate the following NSF best practices to help their loved ones with AD capture as much solid, undisturbed sleep as possible.3 It might be difficult, but if it means their dementia slows in progression, then it’s worthwhile.

  • Maintain a consistent sleep-wake schedule
  • Keep lighting dim at bedtime
  • Expose those with AD to bright natural light in the morning
  • Opt for simple everyday routines and rituals
  • Practice relaxation techniques at bedtime
  • Make the sleeping environment conducive to sleep
    • Keep the space dark and quiet
    • Remove electronics from the room and put away phones and other screens at least one hour before bedtime
    • Maintain a healthy bedroom temperature (not too warm, not too cool)

This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The AlzheimersDisease.net team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.

  1. ScienceDaily. Your source for the latest resource news. https://www.sciencedaily.com/releases/2019/10/191031174650.htm. Accessed November 22, 2019.
  2. PDB-101. Molecular explorations through biology and medicine. https://pdb101.rcsb.org/motm/79. Accessed November 22, 2019
  3. National Sleep Foundation. Alzheimer's Disease and Sleep. https://www.sleepfoundation.org/articles/alzheimers-disease-and-sleep. Access November 22, 2019
  4. Clinical Neurology News. Sleep aids and dementia. https://www.mdedge.com/clinicalneurologynews/article/206002/alzheimers-cognition/sleep-aids-and-dementia-studies-find-both. Access November 22, 2019
  5. University of Arkansas for Medical Sciences Arkansas Geriatric Education Collaborative. High-risk over-the-counter medications for older adults. https://agec.uams.edu/2019/01/07/high-risk-over-the-counter-medications-for-older-adults/. Accessed November 22, 2019
  6. Elsevier. Alzheimer's disease research insights: impacts, trends, opportunities. https://www.elsevier.com/research-intelligence/resource-library/alzheimers-disease-research-insights. Accessed November 22, 2019

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